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EPAC 5376753
CAS No. 302826-61-5
EPAC 5376753( 5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione )
Catalog No. M26202 CAS No. 302826-61-5
EPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 μM in Swiss 3T3 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 195 | Get Quote |
|
| 10MG | 284 | Get Quote |
|
| 25MG | 479 | Get Quote |
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| 50MG | 692 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameEPAC 5376753
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NoteResearch use only, not for human use.
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Brief DescriptionEPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 μM in Swiss 3T3 cells.
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DescriptionEPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 μM in Swiss 3T3 cells.(In Vitro):EPAC 5376753 decreases the conformational changes of EPAC necessary for its activation. EPAC 5376753 inhibits EPAC signaling in cells and EPAC-mediated migration in fibroblasts.
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In VitroEpac is a key mediator of cAMP signaling. EPAC 5376753, the thiobarbituric acid modification of 5225554, has a greater ability to decrease the conformational changes of Epac necessary for its activation and to inhibit Epac signaling in cells. 5376753 selectively inhibits Epac-mediated migration in fibroblasts.
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In Vivo——
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Synonyms5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
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PathwayGPCR/G Protein
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TargetcAMP
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RecptorP-gp
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Research Area——
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Indication——
Chemical Information
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CAS Number302826-61-5
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Formula Weight367.2
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Molecular FormulaC15H8Cl2N2O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESClc1ccc(-c2ccc(C=C3C(=O)NC(=S)NC3=O)o2)c(Cl)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hongzhi Zhang, et al. Anti-tumor Efficacy of Phellamurin in Osteosarcoma Cells:Involvement of the PI3K/AKT/mTOR Pathway. Eur J Pharmacol. 2019 Sep 5;858:172477.
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